Erectile Dysfunction

About Viagra Viagra, an oral therapy for erectile dysfunction, is the citrate salt of Sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When the sexual stimulation causes local release of Nitric Oxide, inhibition of PDE5 by Sildenafil causes increased level of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Viagra is formulated as blue, film-coated rounded-diamond-shaped tablets and is one of the most commonly sold drug for treating male erectile dysfunction or impotence. It is also used for treating pulmonary arterial hypertension (PAH). The drug was developed by the pharmaceutical company Pfizer. Viagra is also informally known as “Vitamin V” or “the Blue Pill”. Ingredients of Viagra Viagra is contra-indicated in patients on nitrate therapy and with a known hypersensitivity to any ingredient of the tablet. In addition to the active ingredient Sildenafil Citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 Aluminum Lake. Comes in the strength of Viagra pills are blue and diamond-shaped with the words “Pfizer” engraved on one side, and its dosage in milligrams engraved on the other side. The various doses of Sildenafil for erectile dysfunction are 25mg, 50mg and 100mg, taken not more than once per day between 30 minutes and 4 hours prior to sexual intercourse. It is usually recommended to start with a dosage of 50mg (or even 25mg) and then lower or raise the dosage as appropriate. Side Effects of Viagra Common side effects include: Sneezing Headache Flushing Dyspepsia Palpitations; and/or Photophobia Priapism Severe hypotension Myocardial infarction Ventricular arrhythmias Stroke; and/or Increased intraocular pressure Care should be exercised by patients who are also taking Protease inhibitors for the treatment of HIV. Patients using protease inhibitors must limit their use of Sildenafil to no more than one 25mg dose every 48 hours. Protease inhibitors inhibit the metabolism of Sildenafil, effectively multiplying the plasma levels and increasing the incidence and severity of side-effects. Some Viagra users have also complained of blue vision (Cyanopsia), including blurriness and loss of peripheral vision. There is also the potential risk of sudden hearing loss associated with the use of PDE5 inhibitors. When used with an alpha blocker, hypotension (low blood pressure) may occur, but this effect does not occur if they are taken at least four hours apart. Availability of Viagra Buying Viagra can be safe, convenient, and affordable and is available at both online or offline pharmacies near you. Prior to buying Viagra online, always get a written prescription. Buy from a site that gives a street address and a telephone number. Better still, buy from a verified Internet Pharmacy Practice – a certified online pharmacy. Buying the generic version of the drug is ill-advised as it could be fake, illegal, or without proven safety or effectiveness record. Amongst Viagra’s rare but serious adverse effects are:

The moment you use the word “generic” in the presence of someone employed by Big Pharma, there are reactions comparable to asking about contraceptives when visiting the Vatican. The reason is simple. The generic manufacturers are allowed to compete with the companies that went through the research and development phase after the patents have expired. All these “dangerous” companies need to do is to wait a few years and then copy all the original research. That means the product is bioequivalent and, under normal circumstances, the regulatory authorities in each country routinely licence the import of the copied drugs which are sold at a big discount. This affects the profits of Big Pharma. So, equally routinely, the lobbyists employed by Big Pharma discuss generic imports with their regulatory authorities, and sometimes those discussions lead to action. First, a word of reassurance. The action I am about to discuss does not affect your ability to buy generic viagra online. Although some thirty drugs are affected, they are treatments for rather different conditions. The FDA has issued two Warning Letters to Ranbaxy Laboratories Ltd, one of the world’s largest manufacturers of generic drugs based in India. These letters assert that Ranbaxy has not maintained proper manufacturing standards in two of its plants. Following the warnings, there is also an Import Alert that allows US customs officials to detain the finished drugs as they enter the US. These Warning Letters are somewhat controversial. There is no suggestion that the thirty drugs named on the list and manufactured in the identified plants are unsafe. There is no product recall and no warning to patients not to continue taking the drugs they already hold. Further, there is no suggestion that the other plants where different drugs are produced are unsafe in any way. This is, at best, a technical violation by the manufacturer. But the effect on Ranbaxy’s reputation has been quite chilling and its share price has fallen. To repeat, this does not affect the generic Viagra manufactured by Ranbaxy. The politics of free trade are always complicated. When the interests of significant local industrial players are involved, there is always going to be a temptation to be protectionist. In this instance, the decision of the FDA looks suspect because it has not required a recall. By its own admission, there is nothing wrong with the generic drugs manufactured by Ranbaxy. They can be safely consumed by existing patients. But the FDA is nevertheless authorising customs to stop imports of new supplies. I suspect that if the FDA had tried to interfere with the import of generic viagra, there would have been am outcry. As it is, there has been little comment outside the financial press discussing the effect on share price.