Medicines

If a reception gipolipidemicheskih products you note the reduction of potency, in any case not to interrupt their own treatment. Discuss this issue with a doctor who will help you to find other drugs. Administration of this site is not responsible for the abolition of autocratic medical treatment.

The drugs used to reduce the level of lipids in the blood (antiateroskleroticheskie, gipolipidemicheskie drugs) typically used in combination with other drugs, which is quite difficult to confirm their effect on potency. Nevertheless, we show that klofibrat lead to erectile dysfunction (impotence) in almost 14% of patients

Mechanism of action gipolipidemicheskih on the potency of drugs is associated with declining availability of cholesterol for the synthesis of testosterone. In addition there accelerated decommissioning androgens.

New gipolipidemicheskie drugs - inhibitors of 3-hydroxy-3-methyl glyutar Coenzyme A reductase (lovastatin, pravastatin, simvastatin) - lead to erectile dysfunction (impotence) for reasons not entirely clear. Dose reduction is accompanied by the elimination of adverse manifestations.

Klofibrat:

Shape of release: capsules.

What is Klofibrat: preparation, correcting lipid metabolism. Reduces elevated levels of lipids in the plasma by reducing the fraction LPONP and LPOP saturated triglycerides. In the liver klofibrat increases metabolism, inhibits the release of hepatic lipoproteins (in particular LPONP), activates lipoproteinlipazu in adipose tissue and increases the excretion of neutral sterols in faeces. Klofibrat increase cholesterol in bile, and improves tolerance to glucose, lowers blood viscosity.

Indications: giperlipoproteinemiya III, IV, V and possibly IIb types of non-correction of diet and physical activity. Diabetic retinopathy ekssudativnaya and hyperlipidaemia caused by diabetes. Ksantomatoz. Stable improvement of fibrinogen associated with atherosclerosis.

How should I take: daily dose - 20-30 mg / kg, the multiplicity of the reception - 2-3 times / day. preferably after meals. The minimum duration of a continuous course of treatment - 3 months.

Side effects: may: gastrointestinal disorders (nausea, vomiting, bowel diskineziya); itchy skin, rash, pain in the muscles (myositis-type), muscle weakness (often in the lower leg), drowsiness, dizziness, headaches. A long application of the drug may develop intrahepatic cholestasis, education gallstones in the gall bladder and biliary tract disease exacerbation zhelchnokamennoy. Seldom in the long-term use of drugs - impotence, alopecia, transient increase of transaminases, increase in body mass due to the delay of fluid in the body.

What should I avoid while taking Klofibrat: breach of terms of liver function and / or kidneys; zhelchnokamennaya disease; gipoproteinemiya, pregnancy, lactation.

Cautions: Not recommended to assign the drug to children under 14 years of age. To appoint a caution to patients with erosive-ulcerative lesions ZHKT in history. Against the backdrop of taking the medication may develop arrhythmias. In the course of treatment requires regular medical supervision. The composition of lipoproteins of blood should be monitored every 2-3 months. It should also control the function of the gall bladder, liver and pancreas, peripheral blood picture. At the same time klofibrat appointment strengthens the effects of indirect anticoagulants, should therefore reduce their initial dose in the treatment dose anticoagulants correcting according to the value of prothrombin time.

Lovastatin:

Shape of production: tablets.

What is Lovastatin:  Inhibits the synthesis of cholesterol in the liver at the stage mevalonovoy acid. Lowers cholesterol, TG, and LPNP LPONP blood; moderately increases the content of HDL, with antiaterogennym action.

Indications: giperlipoproteinemii not correcting a special diet and physical activity.
How should I take Lovastatin: initial dose - 10-20 mg 1 every day during the evening meal. If necessary, increase the dose of 1 every 4 weeks. The maximum daily dose - 80 mg, in 1 or 2 reception (during breakfast and dinner). In the case of reduction in plasma concentrations of total cholesterol to 140 mg/100 ml (3.6 mmol / l) or LPNP-cholesterol up to 75 mg/100 ml (1.94 mmol / L) dose of the drug should be reduced. At the same time appointing lovastatina and drugs that suppress the immune system, lovastatina daily dose should not exceed 20 mg.

Side effects Lovastatin: The drug is generally well tolerated. There may be nausea, diarrhea, constipation, flatulence, dry mouth, disturbance of taste, anorexia, increased levels of hepatic transaminases in the blood, transient increase of CFC in the blood, dizziness, headache, sleep disorders, convulsions, paresthesia. Rarely - mialgii, miopatii, hepatitis. In isolated cases, cholestatic jaundice, mental disturbances, rash, swelling Kvinke, toxic epidermal nekroliz, hemolytic anemia, leukopenia, thrombocytopenia.

What should I avoid while taking Lovastatin: acute liver disease, the constant increase of hepatic transaminases in the serum of unknown etiology, or the possibility of pregnancy, lactation, severe general condition of the patient’s hypersensitivity to the drug.

Cautions: Designate the drug with caution to patients with a history of liver disease, and patients who abuse alcohol. In the case of a persistent increase of hepatic transaminases in the blood and / or CFC is shown lifting the drug. Lovastatinom therapy should be interrupted for long periods or discontinued at the patient’s general condition due to an illness. In patients receiving both cyclosporin, gemfibrozil, or nicotinic acid, there have been cases rabdomioliza with subsequent development of acute renal failure.

Manufacturers: Mevakor (Mevacor) Merck Sharp & Dohme BV, The Netherlands; Medostatin (Medostatin) Medochemie, Cyprus; REKOL (RECOL) THEMIS CHEMICALS, India.

Pravastati:

Structure and Composition: 1 tablet contains sodium pravastatina 10 or 20 mg per pack 10 pcs.

Indications for use: the ineffectiveness of diet with hypercholesterolemia, hypercholesterolemia in combination with gipertriglitseridemiey.

Contraindications: hypersensitivity, aggravation of liver disease, nediagnostsirovannye persistent increase in liver function tests, age (under 18).

Adverse effects: mialgiya, miopatiya and rabdomioliz, increased activity of liver enzymes, rashes on the skin.

Cautions: Application of pregnancy and lactation: Contraindicated. If pregnancy occurs during the period of administration, reception should be discontinued.

Precautions: Gently used in patients with liver diseases in history, with alcohol abuse. Patients should be informed of the need for immediate treatment to the doctor when there is muscle pain, tenderness, or weakness (which may be due to inhibition reductase gidroksimetilglyutaril koenzima-A). Admission should be stopped with a substantial increase in the content and kreatinfosfokinazy suspected miopatiyu.

Simvastatin:

What is Simvastatin: simvastatin - this means the reduction of cholesterol content. He is the inhibitor of 3-hydroxy-3-methyl glutaril koenzima A (HMG-CoA) reductase, an enzyme involved in the formation of cholesterol in the liver. Simvastatin reduces the concentration of total cholesterol, low density lipoproteins cholesterol (LPNP) and triglycerides. Cholesterol content is very low density lipoproteins (LPONP) also decreases, while the cholesterol content of high density lipoproteins (HDL) is increased moderately. In addition simvastin has a number of other positive effects, including improved endothelial function (the inner layer of blood vessels), the drug also has antioxidant effect and inhibits the migration and proliferation of cells in the atherosclerotic process. Simvastatin also promotes gallstone dissolution. Simvastatin is presented in the form of an inactive lactones, which is relatively well absorbed from the gastrointestinal tract and converted into an active form of therapy. The first passage through the liver and metabolized delayed over 79% absorbed drug. It appears mainly with bile and faeces.
The therapeutic effect occurs within 2 weeks, the maximal effect observed after 4 - 6 weeks of treatment.

Indications for use: primary hypercholesterolemia type IIa and IIb. The drug is used as a monotherapy in cases where adherence to diet and other methods of treatment proved insufficient.
Coronary heart disease. The drug reduces the level of total cholesterol and low density lipoproteins cholesterol (LPNP) in patients with ischemic heart disease, and thus reduces the risk of myocardial infarction and death for these patients.

Contraindications: Hypersensitivity to any of the ingredients of the drug, liver disease in the active stage, or a sudden increasing persistent levels of serum transaminases, pregnancy and lactation, porphyria.

Warnings and precautions: simvastatinom treatment may cause improvement in liver enzymes or increased levels of transaminases. In most cases, this increase of small and clinically insignificant, but still recommended to determine the content of the liver enzymes in serum before treatment and regular monitoring during treatment. If the levels of transaminases in serum increased more than 3 times on top of standards, the treatment should be interrupted. Particular caution should be exercised when simvastatin designate patients that regularly consume large amounts of alcohol and / or liver diseases in history. Women of reproductive age who do not have a reliable contraceptive is not recommended Vazilip. Research the safety and effectiveness of simvastatina in children and adolescents under the age of 18 have not yet been carried out.
Simvastatin may cause increasing muscle enzyme kreatinkinazy usually clinically insignificant, but in rare cases can develop miopatiya. Miopatiya manifest as a significant increase in the content of this enzyme (more than 10 times on the normal rate), pain, stiffness and muscular weakness. In the most severe cases can develop rabdomioliz (disintegration of muscle tissue). This can lead to acute renal failure. The risk of developing miopatii higher for those patients who used simvastatin concurrently with drugs that increase levels of serum simvastatina or reinforcing their effects. The risk of developing miopatii also higher in patients with severe renal insufficiency. Should pay attention to the increased activity in the differential diagnosis kreatinfosfokinazy zagrudinnoy pain.

Pregnancy and lactation: the drug is contraindicated during pregnancy and lactation. Women of childbearing age may take simvastatin only in cases where the probability of pregnancy is excluded.

Effects on psycho-physical ability: simvastatin no effect on psychomotor ability while driving or using machinery.

Interaction with other drugs: the simultaneous appointment of simvastatina and cyclosporin, fibroevoy acid derivatives, niacin, erythromycin, clarithromycin, ketokonazola, itrakonazola and nefazodona may cause miopatiyu with rabdomiolizom and renal insufficiency. If you are receiving with ritonavir may increase the concentration levels simvastatina serum. The simultaneous appointment simvastatina and warfarin may enhance the effect last for coagulation of blood, increasing the risk of hemorrhage. Patients simultaneously receiving simvastatin and digoxin contents in serum digoxin may increase, so such patients should be observed accordingly.

Dosage and method of application: the initial dose in the treatment of hypercholesterolemia was 10 mg simvastatina 1 time per day. Depending on the desired effect may be dose uvelichina up to 40 mg. Adjustments to dose is not required for elderly patients and patients with weak or moderate renal insufficiency. The dose of 10 mg simvastatina relatively safe for patients after organ transplants receiving cyclosporin, but the increase in dose is not recommended. Application simvastatina in children and adolescents under 18 years are not recommended.

Overdosage: described several cases of overdose simvastatina; in patients not been any violation or special effects. The highest dose, adopted one patient was 450 mg. If overdose simvastatina should take common measures for such cases (to cause vomiting, activated charcoal to appoint, it is necessary to control the vital functions). It also should monitor liver function and kidney and kreatinkinazy levels in serum.

Adverse effects: the majority of patients is well tolerated simvastatin. Its side effects are usually poorly expressed and are transient in nature. May be marked constipation, nausea, flatulence, indigestion, pain in the abdomen, diarrhea, vomiting, headache, sleep disturbance and improve the content of the liver enzymes; less marked dizziness, feeling of tiredness, muscle weakness, pruritus, and alopecia. Very rarely (in some cases) can be observed on depression, peripheral neyropatiya, impotence, worsening renal function, proteinuria, cataract, dermatomiozit, skin rash and eczema. For the majority of side effects, a direct causal nexus of taking the medication has not been established. Significant, but very rare group of side effects caused by simvastatinom are muscle diseases (miopatiya), manifested as muscle pain and stiffness, as well as increased blood kreatinkinazy (muscle fraction). In very rare cases can develop rabdomioliz, which can lead to kidney failure. If there are violations of the muscular system, it should immediately inform the doctor. Also in case of any other changes that may be associated with the use of drugs should be reported to the doctor.

Storage :
Store at temperatures not above 30 ° C.
Keep out of reach of children.

Holiday preparation:
The product is allowed only on medical prescription.

Packing:
According to 7 tablets per blister.
28 tablets of 10 and 20 mg (4 blisters) in a carton.

Alcohol, Nicotine, Drugs

We did not accidentally put the heading “Alcohol, nicotine, drugs” in the “erectile dysfunction (impotence) as a collateral manifestation of drug therapy.” First, a number of these substances initially created as a drug, and chemical composition can be attributed to the relative for some medicine substances. Secondly, the mechanism of influence of these substances on erectile function in some cases very similar to the mechanism of action of conventional drugs.

However, unlike all the chapters, which describe the influence of drugs on the potency, in this section, we put the following selection:

If the background of the use of alcohol, nicotine and drugs you mark infringement potency, immediately stop taking alcohol, nicotine and drugs. No need to wait, as the impact will be irreversible. Save yourself for your favorite.

Alcohol:

Widely believed that small doses of alcohol lead to emancipation, which may increase the libido. However, excessive and chronic alcohol consumption usually leads to erectile dysfunction (impotence) - in the form of acute or chronic problems.

Most sedative effect of alcohol exceeds the effect of emancipation. Chronic alcoholics suffer from erectile dysfunction (impotence) in half the cases. The main complaints of patients are reducing the severity of orgasm, reduction in sexual excitability, slowing in the onset of ejaculation. Possible reasons for this are the influence of alcohol on pituitary-axis gipotalyamus with the development of Hypogonadism. Often, the reduction of testosterone.

Alcoholism is often accompanied by development polineyropatii leading to neurogenic erectile dysfunction (impotence).

With chronic abuse of alcohol affected the liver and reduces the effectiveness of estrogen metabolism. Additional expression can be ginekomastiya.

If the background of alcohol you mark infringement potency immediately to part with this habit. No need to wait, as the impact will be irreversible. Save yourself for life and loved.

Nicotine:

Nicotine is the most common factor samointoksikatsii. Numerous studies confirmed the influence of nicotine on the natural erectile function. In an equal age groups of smokers have erectile dysfunction (impotence) occurs in 2 times more likely than the nonsmokers.

It is believed that nicotine leads to a local spasm of the internal sramnoy artery (a. pudenda interna). In addition, smoking accelerates the development of atherosclerosis and vascular pathology.

If you smoke and have to observe the violation of potency, to immediately throw this preposterous habit. No need to wait, as the impact will be irreversible. Save yourself for an active life and loved.

Cannabis:

Widespread perception that marijuana improves sexual function. Indeed, in early use, as now spoken, soft drugs, there is increasing severity of orgasm, and even improving erectile function. There is, however, rely on this temporary improvement. With chronic use of marijuana inevitably develop erectile dysfunction (impotence). The main mechanisms of the influence of marijuana on the sexual activity is a decrease in testosterone.

Do not trust your friends, recommending boost their sexual activity tightening of marijuana. The use of “soft drugs”, neminumo lead to erectile dysfunction (impotence).

DIURETICS

Veroshpiron

Diuretics include (diuretic drugs) are drugs that are often appointed primarily for the treatment of uncomplicated hypertension. Naiblee often leads to erectile dysfunction diuretics such as acetazolamide, amiloride, chlorthalidone, indapamide, spironolactone and diuretics tiazidovye.

Effect of diuretic drugs on erectile function demonstrated in many studies, both in the form of self-treatment, and in addition to other drugs (most often in combination with beta-blockers, and metildopoy kaptoprilom). It is believed that the use of diuretics, reduced the blood flow through the penis, because reduced vascular resistance in other areas of the body, and more blood goes there, do not reach the reproductive organs. Nesovsem For understandable reasons, is also the reduction of libido (sex drive) and also disrupted the process of ejaculation.

Spironolactone, an aldosterone antagonists, are believed to hinder the binding of dihydrotestosterone to androgen receptors. This leads to the conversion of testosterone to estradiol. This in turn leads to serious problems with potency and ginekomastii. This is a side spironolactone for direct manifestation depends on the dose and runs after its repeal. The frequency of erectile dysfunction (impotence) when receiving spironolactone to 30%.

If a receiving diuretics (diuretic drugs) developed erectile dysfunction and you’re concerned, do not stop taking medication without consulting your doctor. Many antihypertensive drugs, and your doctor will be able to find a replacement, to change the dose or offer a combination with another drug or switch to the treatment drugs, which affect less than erectile function. These drugs include inhibitors of ACE, such as enalapril and CAPTOPRIL, calcium channel blockers (VERAPAMIL) and the selective alpha-1 blockers.

Erectile dysfunction (impotence) as a marginal manifestations of drug therapy

The modern world is characterized by extensive use of various medications for chronic diseases, whether hypertension, gastric ulcer and 12 rings bowel, depression, elevated blood cholesterol, coronary heart disease and many others. Such diseases, to avoid the development of complications, require constant medical treatment. The accumulation of information on the clinical use of drugs allowed to know that some of them, with a frequency lead to the development of erectile dysfunction (impotence).

This section provides information on the drug groups and individual drugs, use of which can lead to erectile dysfunction (impotence).

If you are taking these drugs, and you have erectile dysfunction, do not interrupt the drug. Discuss with your doctor the possibility of replacing the product or change the dose, perhaps at a combination with another drug. Administration of this site is not responsible for the abolition of autocratic medical treatment.

* Preparations for the treatment of hypertension
o Diuretics include
o Beta-blockers
o Alpha-blockers
o Simpatolitiki
o Vazodilyatatory
* Preparations for the treatment of depressive states
o tricyclic antidepressants
o MAO Inhibitors
o inhibitors of serotonin
o Preparations lithium
* Antipsychotic drugs
* Antidepressants
* H2 blockers
* Hormonal drugs
* Preparations for the reduction of lipids in the blood
* Digoxin
* Nicotine, alcohol and drugs

Causes erectile dysfunction

Medicines
Vascular diseases
Anatomical causes of impotence
Surgical intervention
Endocrine diseases
List of all causes of impotence

Today, there is no doubt that the emergence of erectile dysfunction associated with a variety of reasons, each of which individually and / or in combination with others can lead to unpleasant consequences.

There are five main groups of causes of erectile dysfunction.

1. Psychological disorders

* Depression
* Drugs
* Alcoholism
* Specific psychopathological disorder - fear of sexual impotence, depleted sexual technique, etc.

2. Endocrine disorders

* Decrease the function of sexual glands (Hypogonadism)
* Diabetes
* Prolaktinoma (pituitary tumor)
* Sarcoidosis lesion with some areas of the brain

3. Cardiovascular system disorders:

* Atherosclerotic lesion of blood vessels of the penis on a background of diabetes, smoking, excess cholesterol, hypertension
* Plugging pelvic arteries as a consequence of fractures pelvis
* Violation of the circulation of the blood vessels in the penis (penilny angiospasm), as a result of smoking, of certain medicines
* Violation of the function of venous system of the penis
* A combination of different causes

4. Organic (anatomical) changes of the penis

* Disease Peyroni
* Sclerosis and fibrosis of cavernous tissue of the penis, as a consequence of trauma, injury, inflammatory diseases, etc.)

5. Neurological disorders

* Violation of cerebral circulation
* Diseases of the spinal cord
* Multiple sclerosis
* Peripheral toxic neyropatii
* Parkinson’s disease

It is important to note that in most cases, erectile dysfunction is a consequence of several factors. Thus, according to scientists, 80 percent of all erectile dysfunction, due to the influence of diabetes mellitus, hypertension and smoking. Often, for these reasons stratify psychological problems. That is why finding out specific causes of erectile dysfunction should be performed by qualified and experienced doctor, concentrating exclusively on the problems of their own specialty.